1. Raw materials: The quality of raw materials used in the production of intermediate products can significantly affect the quality of the final product. The raw materials should be of high quality and meet the required standards.

2. Equipment: Manufacturing equipment used in the production of intermediate products should be properly maintained and calibrated to ensure that they function correctly.

3. Personnel: The personnel involved in the manufacturing process should be properly trained to understand and follow the GMP guidelines. This helps to ensure that the process is carried out correctly, and the intermediate products are of the required quality.

4. Environmental conditions: The manufacturing environment should be carefully controlled to prevent contamination, which can affect the quality of the intermediate product and, ultimately, the final product.

5. Process control: The manufacturing process should be closely monitored and controlled to ensure that all stages are conducted correctly. Any deviations from the required parameters should be identified and resolved promptly.